Nicholas M. Riley
Systems Glycobiology enabled by Innovations in Mass Spectrometry and Chemical Biology
About mY Research
The glycocode, or combinatorial patterns of glycosylation that relay biological information, functions in essential roles that govern human health and myriad diseases (e.g., cancer, infectious diseases, autoimmune diseases). However, we lack a fundamental understanding of the rules that define changes in glycosylation, which hinders insight in to how the glycocode contributes to biological function at a molecular level. Our perspectives on the glycocode remain deficient because the non-templated complexity of glycosylation creates analytical challenges that have severely limited our ability to study glycoconjugates. I aim to solve these challenges. I leverage my graduate training in mass spectrometry (MS)-based proteomics and my postdoctoral work in chemical glycobiology to develop innovative bioanalytical and chemical biology technologies to investigate essential principles of glycocode regulation and dysregulation. Specifically, I am interested in using cutting-edge technologies to understand how altered cell surface phenotypes (i.e., glycocalyx status) manifest in cancer progression and drive metastasis. Through a combination of MS-based multi-omics, bioinformatics, and chemical biology, my goal is to use a systems-level approach to glycobiology to further our understanding of human health and disease and advance therapeutic glycoscience.
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